Establishment and evaluation of an early prediction model of hepatorenal syndrome in patients with decompensated hepatitis B cirrhosisRandomized Controlled Trial Published on 2023-01-022023-06-12 Journal: BMC Gastroenterology [Category] B형 간염, [키워드] cirrhosis Hepatitis B virus hepatorenal syndrome Model predictors Retrospective study. [DOI] 10.1186/s12876-022-02618-x PMC 바로가기 [Article Type] Randomized Controlled Trial
Comparison of Wild Type DNA Sequence of Spike Protein from SARS-CoV-2 with Optimized Sequence on The Induction of Protective Responses Against SARS-Cov-2 Challenge in Mouse Model마우스 모델에서 SARS-CoV-2 공격에 대한 보호 반응 유도에 대한 최적화된 서열과 SARS-CoV-2의 스파이크 단백질 야생형 DNA 서열의 비교Article Published on 2022-12-312022-09-11 Journal: Human vaccines & immunotherapeutics [Category] COVID19(2023년), SARS, 비임상, 진단, [키워드] acid Against Antiviral binding breath CD4 CD8+ cellular immune responses cellular immunity challenge clinical trial contributing to COVID-19 CTL demonstrated DNA DNA vaccine expression full-length spike protein hACE2 humoral humoral and cellular immunity IFN-γ immune immune responses immunogen in vitro induction mice Model mouse Neutralizing antibodies optimization optimizations pGX-9501 platform Protective Protective effects protective response RBD binding response robust SARS-CoV-2 sequence spike Spike protein subsequent T cell T cells the vaccine Transgenic mouse Type virus wild-type wild-type sequence. [DOI] 10.1080/21645515.2021.2016201 PMC 바로가기 [Article Type] Article
A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Clinical decision analysis of elective delivery vs expectant management for pregnant individuals with COVID-19–related acute respiratory distress syndromeResearch article Published on 2022-11-012022-10-05 Journal: American journal of obstetrics & gynecology MFM [Category] 임상, [키워드] acute respiratory distress acute respiratory distress syndrome age Analysis cesarean delivery children clinical decision Clinical decision analysis comparable Complication Computer simulation COVID-19 Critical illness death Decision analysis determine Elective Evidence gestation hospital individual individuals iteration lack likelihood management Maternal Model Mortality mortality risk Neonatal Neonates neonatology obstetrics outcome outcomes parameter performed Pregnancy pregnant premature birth quantification risk sensitivity analysis severity spontaneous labor survival syndrome the mean utility Ventilated [DOI] 10.1016/j.ajogmf.2022.100697 [Article Type] Research article
Temporal Events Detector for Pregnancy Care (TED-PC): A rule-based algorithm to infer gestational age and delivery date from electronic health records of pregnant women with and without COVID-19Article Published on 2022-10-312022-11-16 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 치료기술, [키워드] Accuracy age Algorithm Characteristics chronic obstructive clinical information Cohort combating common COVID COVID-19 COVID-19 pandemic Critical detect Detector develop diabete distress EHR Electronic health record event extreme gestation granularity Health identifying information material Model normalized obesity outcomes partnership performed Pregnancy pregnant women Prevalence pulmonary disease Record Respiratory failure resulting SARS-COV-2 infection SARS-CoV-2 viral infection Support syndrome Temporal the timing Validity viral infection with COVID-19 [DOI] 10.1371/journal.pone.0276923 PMC 바로가기
Comparative Assessment of Severe Acute Respiratory Syndrome Coronavirus 2 Variants in the Ferret ModelArticle Published on 2022-10-262022-11-15 Journal: mBio [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] acute respiratory syndrome Airborne transmission Analysis assessment Beta changes Comparative Contact coronavirus coronavirus 2 COVID-19 Critical Delta disease evaluate ferret ferrets genomic variant Heterologous highest histopathological homologous homologous or heterologous Human in vivo infection with SARS-CoV-2 inoculated lineages lowest Mild Model offered pandemic Particle pathogenicity provided Reinfection replicated Replication replication kinetics respiratory respiratory tract risk RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strains SARS-CoV-2 variant Spread Strains Surveillance the spike protein the United State Transmissibility Transmission transmitted upper respiratory tract USA-WA1/2020 variant Variant. variants virulence virus virus virus infection virus load WA1 while [DOI] 10.1128/mbio.02421-22 PMC 바로가기
Murine Hepatitis Virus, a Biosafety Level 2 Model for SARS-CoV-2, Can Remain Viable on Meat and Meat Packaging Materials for at Least 48 HoursArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료기술, [키워드] biosafety Biosafety Level 2 bottleneck BSL2 Can condition conditions contribute coronavirus Coronaviruses COVID-19 case creating detectable determine Evidence facilitate Factor FIVE highest hour hpi hygiene inoculated involved material meat MHV Model murine hepatitis virus notable outbreak packaging material. Particles persistence physical physical distancing plant provide reduction reduction in reservoir resulting SARS-CoV-2 Spread spread of COVID-19 steadily decreased Styrofoam survival tested unpaired t test viability Viable viral infectivity virus [DOI] 10.1128/spectrum.01862-22 PMC 바로가기
Evaluating diagnostic accuracies of Panbio™ test and RT-PCR for the detection of SARS-CoV-2 in Addis Ababa, Ethiopia using Bayesian Latent-Class Models (BLCM)Article Published on 2022-10-192022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] Accuracy Ag-RDTs Bayesian clinical setting cough COVID-19 COVID-19 pandemic CrI criteria cross-sectional diagnostic diagnostic sensitivity diagnostics enrolled evaluate Evaluating exhibited expected females health center hospitals individual majority Model MOST pandemic Patient performed positive positive RT-PCR Rapid rapid antigen test Rapid diagnostic test reference standard reported RT-PCR SARS-CoV-2 sensitivity specificity Study participants symptomatic and asymptomatic the WHO Transmission was done without symptoms [DOI] 10.1371/journal.pone.0268160 PMC 바로가기
Healthcare-Associated COVID-19 across Five Pandemic Waves: Prediction Models and Genomic AnalysesArticle Published on 2022-10-182022-11-16 Journal: Viruses [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] addition analyses Analysis benefit BMI C-reactive protein Cluster cluster analysis Control COVID-19 CRP death ECDC European Factor frailty Genome sequencing genomic Genomic analysis genomic data HAI healthcare worker healthcare-associated COVID-19 Hospital-acquired infection identify Infection management Model Negative predictive value nosocomial outbreak NPV pandemic Patient performed Positive predictive value PPV predict prediction prediction modelling. ROC SARS-CoV-2 SARS-COV-2 infection significantly thrombocyte university hospital variable [DOI] 10.3390/v14102292 PMC 바로가기
Reconstructed Genome-Scale Metabolic Model Characterizes Adaptive Metabolic Flux Changes in Peripheral Blood Mononuclear Cells in Severe COVID-19 PatientsArticle Published on 2022-10-172022-11-15 Journal: International Journal of Molecular Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome adaptive aerobic Analysis anti-inflammatory effect antiviral drugs biogenesis caused change changes in Coronavirus disease 2019 Coronavirus-2 COVID-19 differentially expressed enzyme FASN fatty flux Glycolysis Health Immune cell Inflammation Inflammatory lipids mechanism metabolic metabolic model metabolism metabolism-directed therapy. metabolites Model mononuclear cell nucleotide oxidative phosphorylation pathogenic PBMC PBMCs peripheral Peripheral blood potential therapeutic targets provide reaction reconstructed Regulation responsible retinol SARS-CoV-2 severe COVID-19 patients SLC2A3 therapy Transcriptome Treatment Vitamin [DOI] 10.3390/ijms232012400 PMC 바로가기